ABSTRACT
The symptoms of depressive disorder can be summarized into three dimensions:emotional symptoms,cognitive symptoms and somatic symptoms.Most patients with depressive disorders have various somatic symptoms.The existence of somatic symptoms is often related to the severity of the disease,poor efficacy,and prolonged disease duration.Depressive disorder with somatic symptoms may be a special subtype of depressive disorder.Therefore exploration for its biological mechanisms has an important significance in such patients.This article reviews the clinical characteristics,definitions,and biological mechanisms of somatic symptoms in depressive disorder,and hopes to contribute to an improved understanding of the pathology of depressive disorders.
ABSTRACT
Objective To explore the energy feature of the spontaneous neural activity in depressive patients with diurnal rhythm.Methods Twenty depressive patients with diurnal rhythm,20 depressive patients without diurnal rhythm and 20 gender-,age-,education-matched healthy controls were scanned with 3.0 T MRI Scanner.According to Results of ANOVA,group-wise two sample t-test was completed.The correlation analysis were conducted between ALFF of significant difference brain regions and the score of Hamilton rating scale for depression.Results The brain regions showing significant differences among three groups were located in the right parahippocampal gyrus(MNI:18,-36,-9;K=136),left parietal lobe(MNI:-54,-45,42;K=86),left cerebellum crus(MNI:-84,-60,36;K=86) and right cerebellum crus(MNI:9,-78,-36;K=91)(P0.05).Conclusion The diurnal rhythm observed in depression may be associated with aberrant activity of parahippocampal gyrus.
ABSTRACT
Objective To explore the variations of functional connectivity in depressive episode pa-tients with diurnal rhythm.Methods Totaly 44 patients with depressive episode with diurnal rhythm(rhythm group),58 patients with depressive episode without diurnal rhythm(non-rhythm group)and 56 matched healthy volunteer controls(healthy group)were scanned with 3.0 T MRI Scanner.Functional connectivity (FC)were calculated between suprachiasmatic nucleus(SCN)and whole brain regions.According to results of ANOVA,group-wise two sample t-test was completed.Correlation analysis were conducted between FC of significant difference brain regions and the score of Hamilton rating scale(HAMD-24)for depression.Results The brain regions showing differences among three groups were located in the left medial superior frontal gy-rus(MNI:x=0,y=39,z=51; K=14)and right cerebellum crus 1(MNI:x=39,y=-48,z=-36; K=18) (P<0.05,Alphasim).Compared with non-rhythm group,the FC of rhythm group showed significantly in-creased in the left medial superior frontal gyrus and right triangular inferior frontal gyrus(MNI:x=39,y=27, z=27;K=10)(P<0.05,Alphasim).Compared with healthy group,the FC of non-rhythm group showed sig-nificantly decreased in left medial superior frontal gyrus(P<0.05,Alphasim).Positive correlation was found be-tween FC in left medial superior frontal gyrus and despair score of HAMD-24(r= 0.31,P= 0.041). Conclusion The synergistic increase in SCN and prefrontal activity in patients with depressive episodes with morning heavy night light rhythm which may be involved in the formation mechanism of the diurnal rhythm.